• ISSN 16748301
  • CN 32-1810/R
Volume 30 Issue 4
Apr.  2016
Article Contents

Citation:

Characterization of integrons and novel cassette arrays in bacteria from clinical isloates in China, 2000-2014

  • Received Date: 2015-11-05
    Accepted Date: 2015-12-20

    Fund Project: the National Natural Science Foundation of China (No.81000754 and No.81471994) and the Key Laboratory for Laboratory Medicine of Jiangsu Province of China (No. XK201114).

  • Rapid dissemination of antibiotic resistance genes among bacterial isolates is an increasing problem in China.Integron,a conserved DNA sequence, which is caMed on episomal genetic stoctoes, plays a very important role in development of antibiotic resistance. This systematic analysis was based on MEDLINE and EMBASE databases. We summarized the distribution and proportion of different types of gene cassette arrays of integrons (including class 1,2,3 and atypical class 1 integron) from clinical bacteria isolates in China. Fifty-six literatures were included in this study. Most of the strains were Gram-negative bacteria (94.1%, 7,364/7,822) while only 5.9% strains were Grampositive bacteria. Class 1 integrons were detected in 54.2% (3956/7295) Gram-negative strains. aadA2 was the most popular gene cassette array detected from 60 Gram-positive bacteria while dfrA17-aadA5 were detected in 426 Gramnegative bacteria. This study identified 12 novel gene cassette arrays which have not been previously found in any species. All the novel gene cassette arrays were detected from Gram-negative bacteria. A regional characteristic of distribution of integrons was presented in this study. The results highlight a need for continuous surveillance of integrons and provide a guide for fixture research on integron-mediated bacteria resistance.
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Characterization of integrons and novel cassette arrays in bacteria from clinical isloates in China, 2000-2014

  • 1. Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu,210029, China
  • 2. National Key Clinical Department of Laboratory Medicine, Nanjing, Jiangsu 210029, China
  • 3. Medical Technology Institute ofXuzhou Medical College, Xuzhou, Jiangsu 221002, China
  • 4. Department of Laboratory Medicine, Affiliated Hospital ofXuzhou Medical College, Xuzhou, Jiangsu 221002, China
Fund Project:  the National Natural Science Foundation of China (No.81000754 and No.81471994) and the Key Laboratory for Laboratory Medicine of Jiangsu Province of China (No. XK201114).

Abstract: Rapid dissemination of antibiotic resistance genes among bacterial isolates is an increasing problem in China.Integron,a conserved DNA sequence, which is caMed on episomal genetic stoctoes, plays a very important role in development of antibiotic resistance. This systematic analysis was based on MEDLINE and EMBASE databases. We summarized the distribution and proportion of different types of gene cassette arrays of integrons (including class 1,2,3 and atypical class 1 integron) from clinical bacteria isolates in China. Fifty-six literatures were included in this study. Most of the strains were Gram-negative bacteria (94.1%, 7,364/7,822) while only 5.9% strains were Grampositive bacteria. Class 1 integrons were detected in 54.2% (3956/7295) Gram-negative strains. aadA2 was the most popular gene cassette array detected from 60 Gram-positive bacteria while dfrA17-aadA5 were detected in 426 Gramnegative bacteria. This study identified 12 novel gene cassette arrays which have not been previously found in any species. All the novel gene cassette arrays were detected from Gram-negative bacteria. A regional characteristic of distribution of integrons was presented in this study. The results highlight a need for continuous surveillance of integrons and provide a guide for fixture research on integron-mediated bacteria resistance.

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