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Volume 35 Issue 2
Mar.  2021
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Song Jun, Zhang Jifeng, Xu Jie, Garcia-Barrio Minerva, Chen Y. Eugene, Yang Dongshan. Genome engineering technologies in rabbits[J]. The Journal of Biomedical Research, 2021, 35(2): 135-147. doi: 10.7555/JBR.34.20190133
Citation: Song Jun, Zhang Jifeng, Xu Jie, Garcia-Barrio Minerva, Chen Y. Eugene, Yang Dongshan. Genome engineering technologies in rabbits[J]. The Journal of Biomedical Research, 2021, 35(2): 135-147. doi: 10.7555/JBR.34.20190133

Genome engineering technologies in rabbits

doi: 10.7555/JBR.34.20190133
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  • Corresponding author: Y. Eugene Chen and Dongshan Yang, Center for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, 2800 Plymouth Road, Ann Arbor, MI 48109, USA. Tel/Fax: +1-734-647-5742/+1-734-763-7097, E-mails: echenum@umich.edu and doyang@umich.edu; 
  • Received: 2019-10-22
  • Accepted: 2020-04-29
  • Published: 2020-06-12
  • Issue Date: 2021-03-26
  • The rabbit has been recognized as a valuable model in various biomedical and biological research fields because of its intermediate size and phylogenetic proximity to primates. However, the technology for precise genome manipulations in rabbit has been stalled for decades, severely limiting its applications in biomedical research. Novel genome editing technologies, especially CRISPR/Cas9, have remarkably enhanced precise genome manipulation in rabbits, and shown their superiority and promise for generating rabbit models of human genetic diseases. In this review, we summarize the brief history of transgenic rabbit technology and the development of novel genome editing technologies in rabbits.


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