• ISSN 1674-8301
  • CN 32-1810/R
Volume 33 Issue 1
Jan.  2019
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Article Contents
Park Gi Young, Kwon Dong Rak, Moon Yong Suk. Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits[J]. The Journal of Biomedical Research, 2019, 33(1): 30-37. doi: 10.7555/JBR.32.20180056
Citation: Park Gi Young, Kwon Dong Rak, Moon Yong Suk. Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits[J]. The Journal of Biomedical Research, 2019, 33(1): 30-37. doi: 10.7555/JBR.32.20180056

Low-intensity microcurrent therapy promotes regeneration of atrophied calf muscles in immobilized rabbits

doi: 10.7555/JBR.32.20180056
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  • Corresponding author: Dong Rak Kwon, M.D., Ph.D., Department of Rehabilitation Medicine, Catholic University of Daegu School of Medicine, 33 Duryugongwon-ro 17-gil, Nam-Gu, Daegu 42472, Republic of Korea. Tel/Fax:+ 82-53-650-3627/+ 82-53-622-4687, E-mail: coolkwon@cu.ac.kr or dongrakkwon@hotmail.com
  • Received: 2018-06-14
  • Revised: 2018-06-25
  • Accepted: 2018-07-05
  • Published: 2018-08-20
  • Issue Date: 2019-01-01
  • The purpose of this study was to investigate the intensity-specific regenerative effects of microcurrent therapy on gastrocnemius muscle atrophy induced by cast-immobilization in rabbits. Fifteen rabbits were randomly allocated to 3 groups after cast removal: cast-immobilization and sham microcurrent therapy for 2 weeks (group 1); castimmobilization and microcurrent therapy (25 μA) for 2 weeks (group 2); cast-immobilization and microcurrent therapy (5, 000 μA) for 2 weeks (group 3). Clinical parameters [calf circumference, compound muscle action potential (CMAP) of the tibial nerve, thickness of gastrocnemius muscle], cross sectional area of gastrocnemius muscle fibres, and immunohistochemistry was evaluated. The clinical parameters representing mean atrophic changes in group 2 were significantly lower than those in group 3. The cross sectional area of the gastrocnemius muscle fibres and immunohistochemical parameters in group 2 were significantly greater than those in group 3. The results showed that low-intensity microcurrent therapy can more effectively promote regeneration in atrophied gastrocnemius muscle than high-intensity microcurrent therapy.


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