• ISSN 1674-8301
  • CN 32-1810/R
Volume 31 Issue 4
Jul.  2017
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Lei Chang, Chun-Yu Yin, Hai-Yin Wu, Bin-Bin Tian, Yan Zhu, Chun-Xia Luo, Dong-YaZhu. (+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines[J]. The Journal of Biomedical Research, 2017, 31(4): 306-314. doi: 10.7555/JBR.31.20160138
Citation: Lei Chang, Chun-Yu Yin, Hai-Yin Wu, Bin-Bin Tian, Yan Zhu, Chun-Xia Luo, Dong-YaZhu. (+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines[J]. The Journal of Biomedical Research, 2017, 31(4): 306-314. doi: 10.7555/JBR.31.20160138

(+)-Borneol is neuroprotective against permanent cerebral ischemia in rats by suppressing production of proinflammatory cytokines

doi: 10.7555/JBR.31.20160138
Funds:

This work was supported by grants from National Natural Science Foundation of China (91232304, 31530091, 81571188 and 81222016), the Natural Science Foundation of Jiangsu Province (BK2011029) and Distinguished Young Scientists Fund (BK20130040), and the Collaborative Innovation Center for Cardiovascular Disease Translational Medicine

  • Received: 2016-11-23
  • Revised: 2016-12-08
  • Issue Date: 2017-07-28
  • Stroke is one of the leading causes of disability and death globally. It occurs when a major artery is occluded in the brain and leads to death of cells within the injured tissue. (+)-Borneol, a simple bicyclic monoterpene extracted from traditional Chinese medicine, is widely used in various types of diseases. However, no study has proved the effects of (+)-borneol on functional recovery from permanent ischemic stroke and the mechanism is still unknown. Here, we report that in the rat model of permanent cerebral ischemia, we found that (+)-borneol (1.0 mg/kg) significantly ameliorated infarct size and neurological scores via reducing the expression of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-a) in a dose dependent manner. Notably, (+)-borneol showed long-term effects on the improvement of sensorimotor functions in the photothrombotic model of stroke, which decreased the number of foot faults in the grid-walking task and forelimb asymmetry scores in the cylinder task, at least in part through reducing loss of dendritic spines in the length, brunch number and density. These findings suggest that (+)-borneol could serve as a therapeutic target for ischemic stroke.

     

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