• ISSN 1674-8301
  • CN 32-1810/R
Volume 30 Issue 6
Turn off MathJax
Article Contents

Komal Raina, Sushil Kumar, Deepanshi Dhar, Rajesh Agarwal. Silibinin and colorectal cancer chemoprevention: a comprehensivereview on mechanisms and efficacy[J]. The Journal of Biomedical Research, 2016, 30(6): 452-465. doi: 10.7555/JBR.30.20150111
Citation: Komal Raina, Sushil Kumar, Deepanshi Dhar, Rajesh Agarwal. Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy[J]. The Journal of Biomedical Research, 2016, 30(6): 452-465. doi: 10.7555/JBR.30.20150111

Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy

doi: 10.7555/JBR.30.20150111
Funds:

NCI R01 grant CA112304

  • Received: 05 August 2015
  • Issue Date: November 2016
  • Globally, the risk of colorectal cancer (CRC) as well as the incidence of mortality associated with CRC is increasing. Thus, it is imperative that we look at alternative approaches involving intake of non-toxic natural dietary/non-dietary agents, for the prevention of CRC. The ultimate goal of this approach is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent their progression to more advanced forms of CRC, and use these natural agents as a safe intervention strategy during the clinical course of this deadly malignancy. Over the years, pre-clinical studies have shown that silibinin (a flavonolignan isolated from the seeds of milk thistle, Silybum marianum) has strong preventive and therapeutic efficacy against various epithelial cancers, including CRC. The focus of the present review is to provide a comprehensive tabular summary, categorically for an easy accessibility and referencing, pertaining to the efficacy and associated mechanisms of silibinin against CRC growth and progression.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2902) PDF downloads(435) Cited by()

Related
Proportional views

Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy

doi: 10.7555/JBR.30.20150111
Funds:

NCI R01 grant CA112304

Abstract: Globally, the risk of colorectal cancer (CRC) as well as the incidence of mortality associated with CRC is increasing. Thus, it is imperative that we look at alternative approaches involving intake of non-toxic natural dietary/non-dietary agents, for the prevention of CRC. The ultimate goal of this approach is to reduce the incidence of pre-neoplastic adenomatous polyps and prevent their progression to more advanced forms of CRC, and use these natural agents as a safe intervention strategy during the clinical course of this deadly malignancy. Over the years, pre-clinical studies have shown that silibinin (a flavonolignan isolated from the seeds of milk thistle, Silybum marianum) has strong preventive and therapeutic efficacy against various epithelial cancers, including CRC. The focus of the present review is to provide a comprehensive tabular summary, categorically for an easy accessibility and referencing, pertaining to the efficacy and associated mechanisms of silibinin against CRC growth and progression.

Komal Raina, Sushil Kumar, Deepanshi Dhar, Rajesh Agarwal. Silibinin and colorectal cancer chemoprevention: a comprehensivereview on mechanisms and efficacy[J]. The Journal of Biomedical Research, 2016, 30(6): 452-465. doi: 10.7555/JBR.30.20150111
Citation: Komal Raina, Sushil Kumar, Deepanshi Dhar, Rajesh Agarwal. Silibinin and colorectal cancer chemoprevention: a comprehensive review on mechanisms and efficacy[J]. The Journal of Biomedical Research, 2016, 30(6): 452-465. doi: 10.7555/JBR.30.20150111

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return