• ISSN 1674-8301
  • CN 32-1810/R
Volume 27 Issue 2
Mar.  2013
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Bing Gu, Xing Ke, Shiyang Pan, Yan Cao, Ling Zhuang, Rongbin Yu, Huimin Qian, Genyan Liu, Mingqing Tong. Prevalence and trends of aminoglycoside resistance in Shigella worldwide, 1999-2010[J]. The Journal of Biomedical Research, 2013, 27(2): 103-115. doi: 10.7555/JBR.27.20120125
Citation: Bing Gu, Xing Ke, Shiyang Pan, Yan Cao, Ling Zhuang, Rongbin Yu, Huimin Qian, Genyan Liu, Mingqing Tong. Prevalence and trends of aminoglycoside resistance in Shigella worldwide, 1999-2010[J]. The Journal of Biomedical Research, 2013, 27(2): 103-115. doi: 10.7555/JBR.27.20120125

Prevalence and trends of aminoglycoside resistance in Shigella worldwide, 1999-2010

doi: 10.7555/JBR.27.20120125
Funds:

This research was funded by National Natural Science Foundation of China (No. 81000754), a grant from the Key Laboratory for Laboratory Medicine of Jiangsu Province of China (No. XK201114) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions

  • Received Date: 2012-11-12
  • Publish Date: 2013-03-28
  • Shigellosis causes diarrheal disease in humans in both developed and developing countries, and multi-drug resistance in Shigella is an emerging problem. Understanding changing resistance patterns is important in de-termining appropriate antibiotic treatments. This meta-analysis systematically evaluated aminoglycoside resist-ance in Shigella. A systematic review was constructed based on MEDLINE and EMBASE databases. Random-effect models or fixed-effect models were used based on P value considering the possibility of heterogeneity between studies for meta-analysis. Data manipulation and statistical analyses were performed using software STATA 11.0. By means of meta-analysis, we found a lower resistance to three kinds of aminoglycosides in the Europe-America areas during the 12 year study period than that of the Asia-Africa areas. Kanamycin resist-ance was observed to be the most common drug resistance among Shigella isolates with a prevalence of 6.88% (95%CI: 6.36%-7.43%). Comparison of data from Europe-America and Asia-Africa areas revealed that Shigella flexneri resistance was greater than the resistance calculated for Shigella sonnei. Importantly, S higella sonnei has played a significant role in aminoglycoside-resistance in recent years. Similarly, data showed that resistance to these drugs in children was higher than the corresponding data of adults. In conclusion, aminoglycoside-resistant Shigella is not an unusual phenomenon worldwide. Distribution in Shigella resistance differs sharply based on geographic areas, periods of time and subtypes. The results from the present study highlight the need for con-tinuous surveillance of resistance and control of antibiotic usage.
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Prevalence and trends of aminoglycoside resistance in Shigella worldwide, 1999-2010

doi: 10.7555/JBR.27.20120125
Funds:

This research was funded by National Natural Science Foundation of China (No. 81000754), a grant from the Key Laboratory for Laboratory Medicine of Jiangsu Province of China (No. XK201114) and a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions

Abstract: Shigellosis causes diarrheal disease in humans in both developed and developing countries, and multi-drug resistance in Shigella is an emerging problem. Understanding changing resistance patterns is important in de-termining appropriate antibiotic treatments. This meta-analysis systematically evaluated aminoglycoside resist-ance in Shigella. A systematic review was constructed based on MEDLINE and EMBASE databases. Random-effect models or fixed-effect models were used based on P value considering the possibility of heterogeneity between studies for meta-analysis. Data manipulation and statistical analyses were performed using software STATA 11.0. By means of meta-analysis, we found a lower resistance to three kinds of aminoglycosides in the Europe-America areas during the 12 year study period than that of the Asia-Africa areas. Kanamycin resist-ance was observed to be the most common drug resistance among Shigella isolates with a prevalence of 6.88% (95%CI: 6.36%-7.43%). Comparison of data from Europe-America and Asia-Africa areas revealed that Shigella flexneri resistance was greater than the resistance calculated for Shigella sonnei. Importantly, S higella sonnei has played a significant role in aminoglycoside-resistance in recent years. Similarly, data showed that resistance to these drugs in children was higher than the corresponding data of adults. In conclusion, aminoglycoside-resistant Shigella is not an unusual phenomenon worldwide. Distribution in Shigella resistance differs sharply based on geographic areas, periods of time and subtypes. The results from the present study highlight the need for con-tinuous surveillance of resistance and control of antibiotic usage.

Bing Gu, Xing Ke, Shiyang Pan, Yan Cao, Ling Zhuang, Rongbin Yu, Huimin Qian, Genyan Liu, Mingqing Tong. Prevalence and trends of aminoglycoside resistance in Shigella worldwide, 1999-2010[J]. The Journal of Biomedical Research, 2013, 27(2): 103-115. doi: 10.7555/JBR.27.20120125
Citation: Bing Gu, Xing Ke, Shiyang Pan, Yan Cao, Ling Zhuang, Rongbin Yu, Huimin Qian, Genyan Liu, Mingqing Tong. Prevalence and trends of aminoglycoside resistance in Shigella worldwide, 1999-2010[J]. The Journal of Biomedical Research, 2013, 27(2): 103-115. doi: 10.7555/JBR.27.20120125

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