• ISSN 1674-8301
  • CN 32-1810/R
Volume 25 Issue 6
Nov.  2011
Turn off MathJax
Article Contents

Xiangrong Zuo, Feng Zong, Hui Wang, Qiang Wang, Weiping Xie, Hong Wang. Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α[J]. The Journal of Biomedical Research, 2011, 25(6): 392-401. doi: 10.1016/S1674-8301(11)60052-3
Citation: Xiangrong Zuo, Feng Zong, Hui Wang, Qiang Wang, Weiping Xie, Hong Wang. Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α[J]. The Journal of Biomedical Research, 2011, 25(6): 392-401. doi: 10.1016/S1674-8301(11)60052-3

Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α

doi: 10.1016/S1674-8301(11)60052-3
Funds:

This study was partially supported by the National Natural Sci-ence Foundation of China (No.30971319) and the "Six Talent Peak" Project of Jiangsu Province (No.08-B) and the grant from Open Project Program of the Key Disciplines of the Public Health Depar

  • Received Date: 2011-01-31
  • Iptakalim is a new ATP-sensitive potassium (KATP) channel opener, and it inhibits the proliferation of pulmo-nary arterial smooth muscle cells (PASMCs) and pulmonary vascular remodeling. However, the underlying mech-anism remains unclear. In the present study, we found that iptakalim significantly decreased pulmonary artery pressure, inhibited pulmonary ariery remodeling and PKC-α overexpression in chronic hypoxia in a rat pulmonary hypertension model. Iptakalim reduced hypoxia-induced expression of PKC-α, and abolished the effect of hypoxia on PASMC proliferation significantly in a dose-dependent manner in vitro. Moreover, these effects were abol-ished by glibenclamide, a selective KATP channel antagonist. These results indicate that iptakalim inhibits PASMC proliferation and pulmonary vascular remodeling induced by hypoxia through downregulating the expression of PKC-α. Iptakalim can serve as a novel promising treatment for hypoxic pulmonary hypertension.
  • 加载中
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(2886) PDF downloads(1023) Cited by()

Related
Proportional views

Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α

doi: 10.1016/S1674-8301(11)60052-3
Funds:

This study was partially supported by the National Natural Sci-ence Foundation of China (No.30971319) and the "Six Talent Peak" Project of Jiangsu Province (No.08-B) and the grant from Open Project Program of the Key Disciplines of the Public Health Depar

Abstract: Iptakalim is a new ATP-sensitive potassium (KATP) channel opener, and it inhibits the proliferation of pulmo-nary arterial smooth muscle cells (PASMCs) and pulmonary vascular remodeling. However, the underlying mech-anism remains unclear. In the present study, we found that iptakalim significantly decreased pulmonary artery pressure, inhibited pulmonary ariery remodeling and PKC-α overexpression in chronic hypoxia in a rat pulmonary hypertension model. Iptakalim reduced hypoxia-induced expression of PKC-α, and abolished the effect of hypoxia on PASMC proliferation significantly in a dose-dependent manner in vitro. Moreover, these effects were abol-ished by glibenclamide, a selective KATP channel antagonist. These results indicate that iptakalim inhibits PASMC proliferation and pulmonary vascular remodeling induced by hypoxia through downregulating the expression of PKC-α. Iptakalim can serve as a novel promising treatment for hypoxic pulmonary hypertension.

Xiangrong Zuo, Feng Zong, Hui Wang, Qiang Wang, Weiping Xie, Hong Wang. Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α[J]. The Journal of Biomedical Research, 2011, 25(6): 392-401. doi: 10.1016/S1674-8301(11)60052-3
Citation: Xiangrong Zuo, Feng Zong, Hui Wang, Qiang Wang, Weiping Xie, Hong Wang. Iptakalim, a novel ATP-sensitive potassium channel opener, inhibits pulmonary arterial smooth muscle cell proliferation by downregulation of PKC-α[J]. The Journal of Biomedical Research, 2011, 25(6): 392-401. doi: 10.1016/S1674-8301(11)60052-3

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return