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Huijeong Ahn,Hyuk Moo Kwon,Eunsong Lee,Pyeung-Hyeun Kim,Eui-Bae Jeung,GeunShik Lee.Journal of Biomedical Research,2018,32(6):401-410
Role of inflammasome regulation on immune modulators
Received:November 18, 2017  Revised:December 08, 2017
DOI10.7555/JBR.32.20170120
Keywordsimmune modulator, inflammasome, macrophages, interleukin-1β
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Huijeong Ahn College of Veterinary Medicine and Institute of Veterinary Science, School of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea
Hyuk Moo Kwon College of Veterinary Medicine and Institute of Veterinary Science, School of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea
Eunsong Lee College of Veterinary Medicine and Institute of Veterinary Science, School of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea
Pyeung-Hyeun Kim Department of Molecular Bioscience School of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea
Eui-Bae Jeung Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea
GeunShik Lee College of Veterinary Medicine and Institute of Veterinary Science, School of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea
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Abstract
      Inflammatory responses are essential in eliminating harmful substrates from damaged tissue and inducing recovery. Several cytokines participate in and facilitate this response. Certain cytokines such as interleukin (IL)-1β and IL-18 are initially produced in precursor form in response to toll-like receptor (TLR) ligands and undergo maturation by inflammasomes, which are cytosolic multi-protein complexes containing nucleotide-binding oligomerization domain (NOD)-containing protein 2-like receptors (NLRs). Immune modulators targeting inflammasomes have been investigated to control inflammatory diseases such as metabolic syndrome. However, most immune modulators possessing anti-inflammasome properties attenuate production of other cytokines, which are essential for host defense. In this review, we analyzed he effect of anti-inflammasome agents on the production of cytokines which are not regulated by inflammasome and involving in initial immune responses. As a result, the inflammasome inhibitors are put into three categories: non-effector, stimulator, or inhibitor of cytokine production. Even the stimulator of cytokine production ameliorated symptoms resulting from inflammasome activation in mouse models. Thus, we suggest ideal immune modulators targeting inflammasomes in order to enhance cytokine production while inhibiting cytokine maturation.
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