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Meiqing Sun,Zhanlin Ding,Hong Wang,Guangping Yu,Bingzhi Li,Mingchun Li,Mengmeng Zhen.Journal of Biomedical Research,2018,32(5):380-388
Antifungal effects of BiOBr nanosheets carrying surfactant cetyltrimethylammonium bromide
Received:April 28, 2018  Revised:June 30, 2018
DOI10.7555/JBR.32.20180043
KeywordsBiOBr nanosheets, Candida albicans, antifungal activity, cationic surfactant
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AuthorInstitution
Meiqing Sun Key Laboratory of Systems Bioengineering Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin , China;Wuqing District Center for Disease Control and Prevention, Tianjin , China
Zhanlin Ding Wuqing District Center for Disease Control and Prevention, Tianjin , China
Hong Wang Wuqing District Center for Disease Control and Prevention, Tianjin , China
Guangping Yu Wuqing District Center for Disease Control and Prevention, Tianjin , China
Bingzhi Li Key Laboratory of Systems Bioengineering Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin , China
Mingchun Li Ministry of Education Key Laboratory of Molecular Microbiology and Technology, College of Life Science, Nankai University, Tianjin , China
Mengmeng Zhen Tianjin Key Laboratory of Advanced Functional Porous Materials and Center for Electron Microscopy, Institute for New Energy Materials & Low-Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin , China.
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Abstract
      BiOBr nanosheets are important photocatalytic nanomaterials. However, their biological effects remain to be explored. In this study, we investigated the antifungal effect of BiOBr nanosheets on Candida albicans. Strikingly, the nanosheets strongly inhibited the growth of C. albicans [IC50=(964.7) mg/L], hyphal development and biofilm formation. Compareed to the antifungal effect of the cationic surfactant cetyltrimethylammonium bromide, the inhibitory effect of the nanosheets on fungal pathogen was attributed to cetyltrimethylammonium bromide adsorbed by the nanosheets. Thermal gravity analysis and cetyltrimethylammonium bromide release experiment indicated that only 0.42% cetyltrimethylammonium bromide on BiOBr nanosheets was released. Taken together, this study uncovers the contribution of surfactant released from the nanosheets to their antifungal activity
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