Monocyte to HDL cholesterol ratio predicts obesity-associated cardiac dysfunction

As the prevalence of obesity increases dramatically, obesity-associated cardiac dysfunction constitutes a considerable challenge to human health. This study aims to find more useful lipid/inflammatory markers to predict the risk of obesity-associated cardiac dysfunction. By retrospectively analyzing the clinical characteristics of 5648 disease patients, we found that both plasma level of high-density lipoprotein cholesterol (HDL-C) and blood monocyte count were significantly associated with left ventricular ejection fraction (LVEF) impairment. Univariate and multivariate regression analyses revealed that the monocyte to HDL-C ratio (MHR) was more potent in predicting the risk of LVEF decline than both HDL-C and monocyte. Mediation analysis further indicated a mediating effect of high MHR on the obesity-associated cardiac systolic function decline. As such, our results demonstrate a superior role of MHR in predicting the risk of obesity-associated decline in cardiac systolic function among the routine metabolic/inflammatory markers.