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Yue Xiao, Yue Peng, Chi Zhang, Wei Liu, Kehan Wang, Jing Li. hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220166
Citation: Yue Xiao, Yue Peng, Chi Zhang, Wei Liu, Kehan Wang, Jing Li. hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220166

hucMSC-derived exosomes protect ovarian reserve and restore ovarian function in cisplatin treated mice

doi: 10.7555/JBR.36.20220166
Funds:  This work is supported by National Key Research and Development Program of China (Grants No. 2018YFC1003703 and 2018YFC1004203,) and National Natural Science Foundation of China (31871513).
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  • Corresponding author: Jing Li, Room B101, Xuehai Building, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu 210029, China. Tel: 025-86869504 , E-mail: ljwth@njmu.edu.cn
  • Received: 2022-07-25
  • Revised: 2022-08-28
  • Accepted: 2022-09-04
  • Published: 2022-11-10
  • Anti-cancer therapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicle reserve is extremely sensitive to chemotherapy drugs like cisplatin. Various methods have been explored for fertility preservation in women, especially in prepubertal girls undergoing radiotherapy and chemotherapy because of cancer. In recent years, mesenchymal stem cell-derived exosomes (MSC-exos) have been reported to play an important role in tissue repair and treatment of various diseases. In this study, by using exosomes human umbilical cord-derived from mesenchymal stem cells, we observed that human umbilical cord-derived MSC-exos (hucMSC-exos) after short-term culture improved follicular survival and development while receiving cisplatin treatment. Moreover, the intravenous injection of hucMSC-exos improved ovarian function and ameliorated the inflammatory environment within the ovary. The underlying mechanism of hucMSC-exos on fertility preservation was associated with the down-regulation of p53-related apoptosis and their anti-inflammatory function. Taken together, we proposed that HucMSC-derived exosomes might be a potential approach to improve fertility in women diagnosed with cancer.


  • CLC number: R711.75; R730.53, Document code: A
    The authors reported no conflict of interests.
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