• ISSN 1674-8301
  • CN 32-1810/R
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Evgenii Dmitrievich Kryl'skii, Darya Andreevna Sinitsyna, Tatyana Nikolaevna Popova, Khidmet Safarovich Shikhaliev, Svetlana Mikhajlovna Medvedeva, Larisa Vladimirovna Matasova, Valentina Olegovna Mittova. The new antioxidant 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline has a protective effect against carbon tetrachloride-induced hepatic injury in rats[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220098
Citation: Evgenii Dmitrievich Kryl'skii, Darya Andreevna Sinitsyna, Tatyana Nikolaevna Popova, Khidmet Safarovich Shikhaliev, Svetlana Mikhajlovna Medvedeva, Larisa Vladimirovna Matasova, Valentina Olegovna Mittova. The new antioxidant 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline has a protective effect against carbon tetrachloride-induced hepatic injury in rats[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220098

The new antioxidant 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline has a protective effect against carbon tetrachloride-induced hepatic injury in rats

doi: 10.7555/JBR.36.20220098
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  • Corresponding author: Evgenii Dmitrievich Kryl'skii, Department of Medical Biochemistry and Microbiology, Voronezh State University, Universitetskaya sq. 1, Voronezh, Voronezh region 394018, Russian Federation. Tel: +7-473-2281160 ext. 1111, E-mail: evgenij.krylsky@yandex.ru
  • Received: 2022-04-30
  • Revised: 2022-06-30
  • Accepted: 2022-07-06
  • Published: 2022-07-28
  • Liver diseases with the central pathogenetic mechanism of oxidative stress is one of the main causes of mortality worldwide. Therefore, dihydroquinoline derivatives, which are precursors of hepatoprotectors and have antioxidant activity, are of interest. We have previously found that some compounds in this class have the ability to normalize redox homeostasis under experimental conditions. Here, we initially analyzed the hepatoprotective potential of the dihydroquinoline derivative 1-benzoyl-6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline (BHDQ) for carbon tetrachloride (CCl4)-induced liver injury in rats. Result suggested that BHDQ normalized the alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase in serum. We also observed an improvement in liver tissue morphology related to BHDQ. Animals with CCl4-induced liver injuries treated with BHDQ had less oxidative stress compared to animals with (CCl4)-induced liver injury. BHDQ promoted activation changes in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione transferase on control values in animals with (CCl4)-induced liver injury. BHDQ also activated gene transcription in Sod1 and Gpx1 via nuclear factor erythroid 2-related factor 2 and Forkhead box other 1 factors. Therefore, the compound of concern has a hepatoprotective effect by inhibiting the development of necrotic processes in the liver tissue, through antioxidation.

     

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