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Hong-yan Li, Zhi-you Cai. SIRT3 regulates mitochondrial biogenesis in aging-related diseases[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220078
Citation: Hong-yan Li, Zhi-you Cai. SIRT3 regulates mitochondrial biogenesis in aging-related diseases[J]. The Journal of Biomedical Research. doi: 10.7555/JBR.36.20220078

SIRT3 regulates mitochondrial biogenesis in aging-related diseases

doi: 10.7555/JBR.36.20220078
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  • Corresponding author: Zhi-you Cai, Department of Neurology, Chongqing General Hospital, No. 312 Zhongshan First Road, Yuzhong District, Chongqing 400013, China. Tel/Fax: +86-23-63515796, E-mail: caizhiyou@ucas.ac.cn
  • Received: 2022-04-10
  • Revised: 2022-05-26
  • Accepted: 2022-06-01
  • Published: 2022-06-28
  • Sirtuin 3 (SIRT3), a main family member of mitochondrial deacetylase, targets majority of substrates controlling mitochondrial biogenesis via lysine deacetylation and modulates important cellular functions such as energy metabolism, reactive oxygen species production and clearance, oxidative stress, and aging. Deletion of SIRT3 has deleterious effect on mitochondrial biogenesis, thus leading to the defect in mitochondrial function and insufficient ATP production. Imbalance of mitochondrial dynamics leads to excessive mitochondrial biogenesis, dampening mitochondrial function. Mitochondrial dysfunction plays an important role in several diseases related to aging, such as cardiovascular disease, cancer and neurodegenerative diseases. Peroxisome-proliferator-activated receptor gamma co-activator-1alpha (PGC1α) launches mitochondrial biogenesis through activating nuclear respiratory factors. These factors act on genes, transcribing and translating mitochondrial DNA to generate new mitochondria. PGC1α builds a bridge between SIRT3 and mitochondrial biogenesis. This review described the involvement of SIRT3 and mitochondrial dynamics, particularly mitochondrial biogenesis in aging-related diseases, and further illustrated the role of the signaling events between SIRT3 and mitochondrial biogenesis in the pathological process of aging-related diseases.

     

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