• ISSN 16748301
  • CN 32-1810/R
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A Novel long non-coding RNA NFIA-AS1 is down-regulated in gastric cancer and inhibits proliferation of gastric cancer cells

  • Gastric cancer (GC)is one of the most common malignant gastrointestinal tumors, and its morbidity and mortality account for the second and third place respectively in malignant tumors in China. As a major participant in tumor biology, the abnormal expression of long non-coding RNA (lncRNAs) in cancer cells is closely related to the occurrence and development of tumors and plays the role of oncogenes or tumor suppressor genes.In this study, we identified a novel lncRNA NFIA-AS1 and explored its role and clinical significance in gastric cancer. Real-time quantitative PCR was performed to detect the expression of NFIA-AS1 in tumor tissues andcorresponding normal tissues from 42 pairs of GC samples. The lower expression of NFIA-AS1 wassignificantly associated with larger tumor size, lower histologicalgrade, and advanced TNM stage. Kaplan-meier analysisshowed that NFIA-AS1 expression couldbe used as anindependent predictor of overall survival.We alsodemonstrated that overexpression of NFIA-AS1significantly inhibited the proliferation of gastric cancer cells through affecting p16 levels. In conclusion, our results suggest that the lncRNA NFIA-AS1 may play the role of tumor suppressor gene, and serve asa biomarker for prognosis or progression of gastric cancer.
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    沈阳化工大学材料科学与工程学院 沈阳 110142

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A Novel long non-coding RNA NFIA-AS1 is down-regulated in gastric cancer and inhibits proliferation of gastric cancer cells

  • 1 Department of Anatomy, Histology, and Embryology, The Research Center for Bone and Stem Cells, Nanjing Medical University, Nanjing, People's Republic of China;
  • 2 Department of Oncology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, People's Republic of China;
  • 3 Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center forCancer Personalized Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China

Abstract: Gastric cancer (GC)is one of the most common malignant gastrointestinal tumors, and its morbidity and mortality account for the second and third place respectively in malignant tumors in China. As a major participant in tumor biology, the abnormal expression of long non-coding RNA (lncRNAs) in cancer cells is closely related to the occurrence and development of tumors and plays the role of oncogenes or tumor suppressor genes.In this study, we identified a novel lncRNA NFIA-AS1 and explored its role and clinical significance in gastric cancer. Real-time quantitative PCR was performed to detect the expression of NFIA-AS1 in tumor tissues andcorresponding normal tissues from 42 pairs of GC samples. The lower expression of NFIA-AS1 wassignificantly associated with larger tumor size, lower histologicalgrade, and advanced TNM stage. Kaplan-meier analysisshowed that NFIA-AS1 expression couldbe used as anindependent predictor of overall survival.We alsodemonstrated that overexpression of NFIA-AS1significantly inhibited the proliferation of gastric cancer cells through affecting p16 levels. In conclusion, our results suggest that the lncRNA NFIA-AS1 may play the role of tumor suppressor gene, and serve asa biomarker for prognosis or progression of gastric cancer.

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