• ISSN 16748301
  • CN 32-1810/R
Volume 28 Issue 5
Sep.  2014
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Jia Guo, Xin Chen, Ruxing Xi, Yuwei Chang, Xuanwei Zhang, Xiaozhi Zhang. AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues[J]. The Journal of Biomedical Research, 2014, 28(5): 388-395. doi: 10.7555/JBR.28.20140015
Citation: Jia Guo, Xin Chen, Ruxing Xi, Yuwei Chang, Xuanwei Zhang, Xiaozhi Zhang. AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues[J]. The Journal of Biomedical Research, 2014, 28(5): 388-395. doi: 10.7555/JBR.28.20140015

AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues

doi: 10.7555/JBR.28.20140015
  • Received Date: 2014-02-08
  • Rev Recd Date: 2014-02-28
  • Publish Date: 2014-09-30
  • Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r50.227, P50.045), clinical stage (r50.491, P,0.001) and clinical grade (r50.450, P,0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P.0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r50.240, P 5 0.035) and PPP6c (r5 0.250, P 5 0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.
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AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues

doi: 10.7555/JBR.28.20140015

Abstract: Astrocyte elevated gene-1 (AEG-1) is associated with tumor genesis and progression in a variety of human cancers. This study aimed to explore the significance of AEG-1 in glioma and investigate whether it correlated with radioresistance of glioma cells. Immunohistochemical staining showed that the intensity of AEG-1, CD133 and PPP6c protein expression in glioma tissues increased significantly, mainly in the cytoplasm. The expression rate of AEG-1, CD133 and PPP6c were 85.9% (67/78), 60.3% (47/78) and 65.8% (51/78), respectively. AEG-1 expression was correlated with age (r50.227, P50.045), clinical stage (r50.491, P,0.001) and clinical grade (r50.450, P,0.001). No correlation was found between AEG-1 expression and other clinicopathologic parameters (P.0.05). The expression of AEG-1 was positively correlated with the expression of CD133 (r50.240, P 5 0.035) and PPP6c (r5 0.250, P 5 0.027). In addition, retrieved data on TCGA implied co-occurrence of genomic alterations of AEG-1 and PPP6c in glioblastoma. Our findings indicate that AEG-1 is positively correlated with CD133 and AEG-1 expression. It may play an important role in the progression of glioma and may serve as potential novel marker of chemoresistance and radioresistance.

Jia Guo, Xin Chen, Ruxing Xi, Yuwei Chang, Xuanwei Zhang, Xiaozhi Zhang. AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues[J]. The Journal of Biomedical Research, 2014, 28(5): 388-395. doi: 10.7555/JBR.28.20140015
Citation: Jia Guo, Xin Chen, Ruxing Xi, Yuwei Chang, Xuanwei Zhang, Xiaozhi Zhang. AEG-1 expression correlates with CD133 and PPP6c levels in human glioma tissues[J]. The Journal of Biomedical Research, 2014, 28(5): 388-395. doi: 10.7555/JBR.28.20140015

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