• ISSN 1674-8301
  • CN 32-1810/R
Volume 27 Issue 1
Jan.  2013
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Zhenghui Gordon Jiang, Simon C. Robson, Zemin Yao. Lipoprotein metabolism in nonalcoholic fatty liver disease[J]. The Journal of Biomedical Research, 2013, 27(1): 1-13. doi: 10.7555/JBR.27.20120077
Citation: Zhenghui Gordon Jiang, Simon C. Robson, Zemin Yao. Lipoprotein metabolism in nonalcoholic fatty liver disease[J]. The Journal of Biomedical Research, 2013, 27(1): 1-13. doi: 10.7555/JBR.27.20120077

Lipoprotein metabolism in nonalcoholic fatty liver disease

doi: 10.7555/JBR.27.20120077
  • Received Date: 2012-07-10
  • Publish Date: 2013-01-28
  • Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists between NAFLD and dyslipidemia, a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins. Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins; they not only play an extracellular role in lipid transport between vital organs through circulation, but also play an important intracellu-lar role in hepatic lipoprotein assembly and secretion. The liver functions as the central hub for lipoprotein metab-olism, as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis, potential diagnosis, and treatment of NAFLD.
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Lipoprotein metabolism in nonalcoholic fatty liver disease

doi: 10.7555/JBR.27.20120077

Abstract: Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists between NAFLD and dyslipidemia, a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins. Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins; they not only play an extracellular role in lipid transport between vital organs through circulation, but also play an important intracellu-lar role in hepatic lipoprotein assembly and secretion. The liver functions as the central hub for lipoprotein metab-olism, as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis, potential diagnosis, and treatment of NAFLD.

Zhenghui Gordon Jiang, Simon C. Robson, Zemin Yao. Lipoprotein metabolism in nonalcoholic fatty liver disease[J]. The Journal of Biomedical Research, 2013, 27(1): 1-13. doi: 10.7555/JBR.27.20120077
Citation: Zhenghui Gordon Jiang, Simon C. Robson, Zemin Yao. Lipoprotein metabolism in nonalcoholic fatty liver disease[J]. The Journal of Biomedical Research, 2013, 27(1): 1-13. doi: 10.7555/JBR.27.20120077

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