• ISSN 16748301
  • CN 32-1810/R
Volume 32 Issue 4
Apr.  2018
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Citation:

Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea

  • Received Date: 2017-08-08
    Accepted Date: 2017-11-09

    Fund Project: This work was supported by the National Research Foundation of Korea Grant, funded by the Korean Government (Ministry of Education, Science and Technology) [NRF-355-2010-1-E00026 and 2012R1- A1A2044765]

  • There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations, but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway. The effects of vitamin D intake, vitamin D related genetic polymorphisms, and their association with the incidence of gastric cancer were investigated in a hospital case-control study, including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex. Correlations between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of subjects. No statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls, nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate analyses. Vitamin D intake significantly correlated with the circulating 25-hydroxyvitamin D levels, but not with the active form of the vitamin, 1,25-dihydroxyvitamin D. There were no statistically significant interactions between vitamin D intake, and VDR or TXNIP polymorphisms. This study suggests that dietary vitamin D intake is not associated with gastric cancer risk, and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.
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Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea

  • 1. Departments of Preventive Medicine and Medical Research Institute, College of Medicine
  • 2. Departments of Surgery, College of Medicine
  • 3. Departments of Internal Medicine, College of Medicine
  • 4. Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea
  • 5. Department of Surgery, College of Medicine, Eulji University, Daejon 301746, Korea
  • 6. Department of Surgery, Asan Medical Center, College of Medicine, Ulsan University, Seoul 138736, Korea
Fund Project:  This work was supported by the National Research Foundation of Korea Grant, funded by the Korean Government (Ministry of Education, Science and Technology) [NRF-355-2010-1-E00026 and 2012R1- A1A2044765]

Abstract: There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations, but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway. The effects of vitamin D intake, vitamin D related genetic polymorphisms, and their association with the incidence of gastric cancer were investigated in a hospital case-control study, including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex. Correlations between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of subjects. No statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls, nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate analyses. Vitamin D intake significantly correlated with the circulating 25-hydroxyvitamin D levels, but not with the active form of the vitamin, 1,25-dihydroxyvitamin D. There were no statistically significant interactions between vitamin D intake, and VDR or TXNIP polymorphisms. This study suggests that dietary vitamin D intake is not associated with gastric cancer risk, and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.

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