• ISSN 16748301
  • CN 32-1810/R
Volume 26 Issue 1
Jan.  2012
Article Contents

Citation:

Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium

  • Received Date: 2011-06-20

    Fund Project: This study was supported by grant No. 30872453 (to Dr. Wang) from National Natural Science Foundation of China and No. BK2008166 (to Dr. Wang) from Natural Science Foundation of Jiangsu Province and No. 2008-11 (to Dr. Wang) from Technology Bureau of Suzh

  • Parthenolide (PTN), a selective nuclear factor kappa B (NF-κB) inhibitor, has been used extensively to inhibit NF-κB activation. The duration of the inhibitory effect of PTN on NF-κB in vivo remains unclear. This study was to determine whether a lipopolysaccharide (LPS) challenge 6, 12 and 24 h after the administration of PTN could activate NF-κB. Rats were devided into five groups. The rats in the PTN, PTN+LPS and DMSO groups were in-jected intraperitoneally with PTN or DMSO. After 6, 12 or 24 h, LPS was administered in LPS and PTN+LPS groups. The expressions of NF-κB p50, IκBα and p-IκBα were inhibited in both PTN and PTN+LPS group at end of 6 and 12 h and no effects at 24 h. In summary, myocardial NF-κB expression occurs 1 h after the administration of LPS. PTN blocks this effect given at 6 h and no inhibitory effect 24 h after administration in vivo.
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Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium

  • 1. Department of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China
  • 2. Department of Anesthesiology, the Second Affiliated Hospital of Soochow University, Suzhou 215004, China/Institute of Neuroscience, Soochow University, Suzhou 215004, China
  • 3. Institute of Neuroscience, Soochow University, Suzhou 215004, China
  • 4. Department of Anesthesiology and Pain Medicine, University of California Davis, Davis, CA 95616, USA
Fund Project:  This study was supported by grant No. 30872453 (to Dr. Wang) from National Natural Science Foundation of China and No. BK2008166 (to Dr. Wang) from Natural Science Foundation of Jiangsu Province and No. 2008-11 (to Dr. Wang) from Technology Bureau of Suzh

Abstract: Parthenolide (PTN), a selective nuclear factor kappa B (NF-κB) inhibitor, has been used extensively to inhibit NF-κB activation. The duration of the inhibitory effect of PTN on NF-κB in vivo remains unclear. This study was to determine whether a lipopolysaccharide (LPS) challenge 6, 12 and 24 h after the administration of PTN could activate NF-κB. Rats were devided into five groups. The rats in the PTN, PTN+LPS and DMSO groups were in-jected intraperitoneally with PTN or DMSO. After 6, 12 or 24 h, LPS was administered in LPS and PTN+LPS groups. The expressions of NF-κB p50, IκBα and p-IκBα were inhibited in both PTN and PTN+LPS group at end of 6 and 12 h and no effects at 24 h. In summary, myocardial NF-κB expression occurs 1 h after the administration of LPS. PTN blocks this effect given at 6 h and no inhibitory effect 24 h after administration in vivo.

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