• ISSN 1674-8301
  • CN 32-1810/R
Volume 31 Issue 5
Sep.  2017
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Article Contents
Sang R. Lee, Seung-yeon Lee, Sang-yun Kim, Si-yun Ryu, Bae-kuen Park, Eui-Ju Hong. Hydroxylation and sulfation of sex steroid hormones ininflammatory liver[J]. The Journal of Biomedical Research, 2017, 31(5): 437-444. doi: 10.7555/JBR.31.20170031
Citation: Sang R. Lee, Seung-yeon Lee, Sang-yun Kim, Si-yun Ryu, Bae-kuen Park, Eui-Ju Hong. Hydroxylation and sulfation of sex steroid hormones in inflammatory liver[J]. The Journal of Biomedical Research, 2017, 31(5): 437-444. doi: 10.7555/JBR.31.20170031

Hydroxylation and sulfation of sex steroid hormones in inflammatory liver

doi: 10.7555/JBR.31.20170031
Funds:

This work was supported by research fund of Chungnam National University

  • Received: 2017-03-03
  • Revised: 2017-04-10
  • Issue Date: 2017-09-22
  • Sex steroids, also known as gonadal steroids, are oxidized with hydroxylation by cytochrome P450, glucuronidation by UDP-glucuronosyltransferase, sulfation by sulfotransferase, and O-methylation by catechol Omethyltransferase. Thus, it is important to determine the process by which inflammation influences metabolism of gonadal hormones. Therefore, we investigated the mechanism of metabolic enzymes against high physiologic inflammatory response in vivo to study their biochemical properties in liver diseases. In this study, C57BL/6N mice were induced with hepatic inflammation by diethylnitrosamine (DEN) exposure. We observed upregulation of Cyp19a1, Hsd17b1, Cyp1a1, Sult1e1 in the DEN-treated livers compared to the control-treated livers using real time PCR. Moreover, the increased Cyp19a1 and Hsd17b1 levels support the possibility that estrogen biosynthesis from androgens are accumulated during inflammatory liver diseases. Furthermore, the increased levels of Cyp1a1 and Cyp1b1 in the hydroxylation of estrogen facilitated the conversion of estrogen to 2- or 4-hydroxyestrogen, respectively. In addition, the substantial increase in the Sult1e1 enzyme levels could lead to sulfate conjugation of hydroxyestrogen. The present information supports the concept that inflammatory response can sequester sulfate conjugates from the endogenous steroid hormones and may suppress binding of sex steroid hormones to their receptors in the whole body.

     

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