• ISSN 1674-8301
  • CN 32-1810/R
Volume 29 Issue 3
May  2015
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Xiaofan Yang, Bin Sun, Huijuan Wang, Cheng Yin, Xiaole Wang, Xiaohui Ji. Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling[J]. The Journal of Biomedical Research, 2015, 29(3): 232-240. doi: 10.7555/JBR.29.20130037
Citation: Xiaofan Yang, Bin Sun, Huijuan Wang, Cheng Yin, Xiaole Wang, Xiaohui Ji. Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling[J]. The Journal of Biomedical Research, 2015, 29(3): 232-240. doi: 10.7555/JBR.29.20130037

Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling

doi: 10.7555/JBR.29.20130037
  • Received: 2013-03-27
  • Revised: 2013-07-21
  • Issue Date: 2015-05-29
  • We sought to investigate the expression of Fas and FasL on T cell surface and caspase 8 involvement in T cell apoptosis promoted by serum IL-10 in systemic lupus erythematosus (SLE) patients. Cells and sera were obtained from 35 SLE patients. Apoptosis of T cells in patients with SLE was increased and associated with the SLE disease activity index (SLEDAI). Elevated expression of Fas and FasL on T cell surface contributed to increased apoptosis of T cells. Increased IL-10 in the sera of SLE patients was capable of inducing Fas and FasL expression on CD4+T cell surface, promoting apoptosis of this cell subset. Decreased IL-10 serum levels and low expression of Fas were found in 5 patients of the first follow-up group after 2-month treatment. In another group with one-year treatment, the SLEDAI declined to inactive scores. Serum IL-10 was decreased significantly, and expression of Fas and FasL on T cells was also reduced. Declined apoptosis was predominant only in CD4+T cell subset. When sera with high level of IL-10 were used to culture PBMCs from healthy controls, activated caspase 8 was elevated in CD3+T, CD4+T and CD8+T cells. The study showed that serum IL-10 induced apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling. Increased apoptosis of T cells contributes to autoantigen burden, which is pathogenic in the development of SLE.

     

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