Title: Association between Pri-miR-34b/c rs4938723 polymorphism and bladder cancer risk


Authors: Mohammad Hashemi1,2, Vahed Hasanpour3, Hiva Danesh2, Fatemeh Bizhani2, Behzad Narouie4


Institutions: 1Cellular and Molecular Research Center, 2Department of Clinical Biochemistry, School of Medicine, 3Student Research Committee, Zahedan University of Medical Sciences, Zahedan, Sistan and Baluchistan 98167-43181, Iran; 4Urology and Nephrology Research Center, Department of Urology, Shahid Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Tehran 198396-3113, Iran.


Abstract: Several studies examined the impact of miR-34b/c rs4938723 polymorphism and cancer risk, but the findings are inconsistent. However, no study has been conducted to inspect the impact of miR-34b/c polymorphism on bladder cancer. This study aimed to assess possible association between rs4938723 polymorphism and bladder cancer risk. This case-control study was done on 136 pathologically proven bladder cancer patients and 144 controls. Genotyping of Pri-miR-34b/c rs4938723 polymorphism was achieved by using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Our findings did not show any statistically significant differences in genotype and allele frequencies between bladder cancer and controls. Larger sample sizes with diverse ethnicities are required to validate our findings.


Keywords: Pri-miR-34 b/c, bladder cancer, polymorphism, microRNA


Full Text: JBR-2017-0044.pdf


J Biomed Res published on 10 October 2017, https://doi.org/10.7555/JBR.31.20170044