Title: A meta-analysis of caspase-8 -652 6N del polymorphism and digestive tract cancer risk
Authors: Haina Du1, Guoxin Song2, Mingzhi Fang1, Yongqian Shu3, Xin Zhao4, Lingjun Zhu3
Institutions: 1Department of Oncology, the Third Affiliated Hospital of Nanjing University of T.C.M, Nanjing, Jiangsu 210000, China; 2Departments of Pathology, 3Oncology, 4Pneumology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, China.
Abstract: Caspase-8 (CASP8) is one key regulator of apoptosis of T lymphocytes and is encoded by the CASP8 gene. It has been reported that the six-nucleotide deletion polymorphism (-652 6N del) of the CASP8 gene had effect on some cancer risk. Few studies explored the association between CASP8 gene polymorphism and digestive tract cancer risk. To evaluate the association between the CASP8 -652 6N del polymorphism and the risk of digestive tract cancer, we conducted this meta-analysis. We found that CASP8-652 6N del polymorphism was associated with a significantly reduced risk of digestive tract cancer in the co-dominant model (del/del vs. ins/ins: OR = 0.82, 95%CI = 0.72–0.95; del/ins vs. ins/ins: OR = 0.92, 95%CI = 0.87–0.97; dominant model (del/ins + del/del vs. ins/ins: OR = 0.91, 95%CI = 0.87–0.96, recessive model: del/del vs. del/ins + ins/ins: OR = 0.85, 95%CI = 0.75–0.97). In the stratified analysis by cancer types, we found that all genetic models had protective effect on gastric cancer. Similar results were observed for colorectal cancer under heterozygote comparison and dominant model, but not under homozygote comparison or recessive model. In addition, a significantly decreased risk was found on esophageal cancer for most genetic models, except heterozygote comparison. When stratified by ethnicity and source of control, an evidently decreased risk was identified in the Asian populations and population-based studies. In conclusion, there exists an association between the CASP8 -652 6N del polymorphism and reduced digestive cancer risk, especially among Asians and population-based studies.
Keywords: caspases-8, polymorphism, digestive tract cancer risk
Full Text: JBR-2016-0030.pdf JBR-2016-0030-supplementary.pdf
J Biomed Res published on 28 November 2017, https://doi.org/10.7555/JBR.32.20160030