Title: Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea


Authors: Sang-Yong Eom1, Dong-Hyuk Yim1, Dae-Hoon Kim2, Hyo-Yung Yun2, Young-Jin Song2, Sei-Jin Youn3, Taisun Hyun4, Joo-Seung Park5, Byung Sik Kim6, Yong-Dae Kim1, Heon Kim1


Institutions: 1Departments of Preventive Medicine and Medical Research Institute, 2Surgery, 3Internal Medicine, College of Medicine; 4Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea; 5Department of Surgery, College of Medicine, Eulji University, Daejon 301746, Korea; 6Department of Surgery, Asan Medical Center, College of Medicine, Ulsan University, Seoul 138736, Korea.


Abstract: There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations, but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway. The effects of vitamin D intake, vitamin D related genetic polymorphisms, and their association with the incidence of gastric cancer were investigated in a hospital case-control study, including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex. Correlations between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of subjects. No statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls, nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate analyses. Vitamin D intake significantly correlated with the circulating 25-hydroxyvitamin D levels, but not with the active form of the vitamin, 1,25-dihydroxyvitamin D. There were no statistically significant interactions between vitamin D intake, and VDR or TXNIP polymorphisms. This study suggests that dietary vitamin D intake is not associated with gastric cancer risk, and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.


Keywords: gastric cancer, vitamin D, vitamin D receptor, gene-environment interaction


Full Text: JBR-2017-0089.pdf


J Biomed Res published on 03 January 2018, https://doi.org/10.7555/JBR.32.20170089