Title: Association of serum lipids and epithelial ovarian cancer severity in a group of Chinese patients
Authors: Yi Zhang1, Jing Wu2, Junya Liang4, Xing Huang1, Lei Xia1, Dawei Ma1, Xinyu Xu1, Pingping Wu3
Institutions: 1 Department of Pathology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China, 210000, firstname.lastname@example.org; 2 Department of Radiation Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China, 210000, email@example.com; 3Department of Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China, 210000, Wupingping210009@126.com; 4The Public Health School of Nanjing Medical University, Nanjing, Jiangsu, China, 210000, firstname.lastname@example.org.
Abstract: Background: While obesity and fatty intake have been associated with the risk and prognosis of epithelial ovarian cancer (EOC), the connection between the lipid levels and EOC phenotype remains controversial. Methods: We conducted a retrospective study at Jiangsu Oncology Hospital, China (2011–2017) that enrolled 349 EOC patients. The variables analyzed included the age at diagnosis, blood pressure, level of glucose, body mass index (BMI), lipid levels and clinical parameters. The EOC severity was defined using the clinical symptoms and pathologic stage. Univariate analysis of the clinical factors according to the severity status of EOC was followed by logistic regression analysis to identify clinical factors significantly associated with EOC severity. Results: Univariate analysis indicated that age, BMI, triglyceride(TG), and high density lipoproteins(HDL) differed significantly among the different stages of cancer (p < 0.05). In the logistic regression model, elevated TG (OR:1.883; 95% CI = 1.207-2.937), low HDL (OR:0.497; 95% CI = 0.298-0.829) levels were significantly associated with the high-severity EOC. Conclusion: Our data indicate that the high triglyceride and low HDL levels correlate with a high severity of EOC. These data produce important assumptions about the potential relationship between the lipid pathway and the EOC phenotype and development.
Keywords: Triglycerides, Epithelial ovarian cancer, High density lipoproteins, Dyslipidemia, Clinical data statistics
Full Text: JBR-2017-0096 pre-proof.pdf
J Biomed Res published on 05 June 2018, https://doi.org/10.7555/JBR.32.20170096