Title: Role of inflammasome regulation on immune modulators

 

Authors: Huijeong Ahn1, Hyuk Moo Kwon1, Eunsong Lee1, Pyeung-Hyeun Kim2, Eui-Bae Jeung3, Geun-Shik Lee1

 

Institutions: 1College of Veterinary Medicine and Institute of Veterinary Science; 2Department of Molecular Bioscience, School of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea; 3Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.

 

Abstract: Inflammatory responses are essential in eliminating harmful substrates from damaged tissue and inducing recovery. Several cytokines participate in and facilitate this response. Certain cytokines such as interleukin (IL)-1β and IL-18 are initially produced in precursor form in response to toll-like receptor (TLR) ligands and undergo maturation by inflammasomes, which are cytosolic multi-protein complexes containing nucleotide-binding oligomerization domain (NOD)-containing protein 2-like receptors (NLRs). Immune modulators targeting inflammasomes have been investigated to control inflammatory diseases such as metabolic syndrome. However, most immune modulators possessing anti-inflammasome properties attenuate production of other cytokines, which are essential for host defense. In this review, we analyzed the effect of anti-inflammasome agents on the production of cytokines which are not regulated by inflammasome and involving in initial immune responses. As a result, the inflammasome inhibitors are put into three categories: non-effector, stimulator, or inhibitor of cytokine production. Even the stimulator of cytokine production ameliorated symptoms resulting from inflammasome activation in mouse models. Thus, we suggest ideal immune modulators targeting inflammasomes in order to enhance cytokine production while inhibiting cytokine maturation.

 

Keywords: immune modulator, inflammasome, macrophages, interleukin-1β

 

Full Text: JBR-2017-0120.pdf

 

J Biomed Res published on 12 February 2018, https://doi.org/10.7555/JBR.32.20170120