Title: Postprandial hyperglycemia and postprandial hypertriglyceride-mia in type 2 diabetes


Authors: Toru Hiyoshi1, Mutsunori Fujiwara1,2, Zemin Yao3


Institutions: 1Division of Diabetes and Endocrinology, Department of Internal Medicine, Japanese Red Cross Medical Center, Tokyo, Japan; 2Department of Laboratory Medicine, Japanese Red Cross Medical Center, Tokyo, Japan; 3Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada.


Abstract: Postprandial glucose level is an independent risk factor for cardiovascular disease that exerts effects greater than glucose levels at fasting state, whereas increase in serum triglyceride level, under both fasting and postprandial conditions, contributes to the development of arteriosclerosis. Insulin resistance is a prevailing cause of abnormalities in postabsorptive excursion of blood glucose and postprandial lipid profile. Excess fat deposition renders a vicious cycle of hyperglycemia and hypertriglyceridemia in the postprandial state, and both of which are contributors to atherosclerotic change of vessels especially in patients with type 2 diabetes mellitus. Several therapeutic approaches for ameliorating each of these abnormalities have been attempted, including various antidiabetic agents or new compounds targeting lipid metabolism.


Keywords: postprandial hyperglycemia, postprandial hypertriglyceridemia, type 2 diabetes mellitus, atherosclerosis


Full Text: JBR-2016-0164.pdf


J Biomed Res published on 16 May 2017, doi:10.7555/JBR.31.20160164