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Minbo Zang,Qiao Zhou,Yunfei Zhu,Mingxi Liu,Zuomin Zhou.Journal of Biomedical Research,2018,32(6):442-453
Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice
Received:February 10, 2017  Revised:February 17, 2017
DOI10.7555/JBR.31.20170023
KeywordsNon-Hodgkin lymphoma, chemotherapy, bendamustine, mice, spermatozoa, toxicology
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Minbo Zang State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu , China.
Qiao Zhou State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu , China.
Yunfei Zhu State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu , China.
Mingxi Liu State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu , China.
Zuomin Zhou State Key Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing, Jiangsu , China.
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Abstract
      Non-Hodgkin lymphoma (NHL) is one of the most common cancers affecting men of reproductive age. The high response rate of bendamustine as first-line reatment for NHL, coupled with young age of patients, makes elucidation of the impact of treatment on male reproduction important. Our aim was to determine the effects of bendamustine on male reproduction by animal model. Male mice were treated with bendamustine (40 mg/kg) through tail vein injection while cisplatin was given as a standard (3 mg/kg) through intraperitoneal injection. After 3 weeks, bendamustine induced weight loss and sperm morphology abnormalities were compared to the control. Additionally, sperm with folded tails were the most frequent abnormality in bendamustine-treated mice. But the mechanism of sperm abnormality induced by bendamustine remains to bevelucidated. These results indicate bendamustine may affect sprmatozoa of patients who have been treated for NHL.
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