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Sang-Yong Eom,Dong-Hyuk Yim,Dae-Hoon Kim,Hyo-Yung Yun,Young-Jin Song,SeiJin Youn,Taisun Hyun,Joo-Seung Park,Byung Sik Kim,Yong-Dae Kim,Heon Kim.Journal of Biomedical Research,2018,32(4):257-263
Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea
Received:August 08, 2017  Revised:November 09, 2017
DOI10.7555/JBR.32.20170089
Keywordsgastric cancer, vitamin D, vitamin D receptor, gene-environment interaction
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Sang-Yong Eom Departments of Preventive Medicine and Medical Research Institute, College of Medicine
Dong-Hyuk Yim Departments of Preventive Medicine and Medical Research Institute, College of Medicine
Dae-Hoon Kim Departments of Surgery, College of Medicine
Hyo-Yung Yun Departments of Surgery, College of Medicine
Young-Jin Song Departments of Surgery, College of Medicine
SeiJin Youn Departments of Internal Medicine, College of Medicine
Taisun Hyun Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea
Joo-Seung Park Department of Surgery, College of Medicine, Eulji University, Daejon , Korea
Byung Sik Kim Department of Surgery, Asan Medical Center, College of Medicine, Ulsan University, Seoul , Korea
Yong-Dae Kim Departments of Preventive Medicine and Medical Research Institute, College of Medicine
Heon Kim Departments of Preventive Medicine and Medical Research Institute, College of Medicine
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Abstract
      There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations, but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway. The effects of vitamin D intake, vitamin D related genetic polymorphisms, and their association with the incidence of gastric cancer were investigated in a hospital case-control study, including 715 pairs of newly diagnosed gastric cancer patients and controls matched for age and sex. Correlations between vitamin D intake and plasma vitamin D concentrations were also assessed in a subset of subjects. No statistically significant difference was observed in the dietary intake of vitamin D between the patients and controls, nor were there any evident associations between vitamin D intake and risk of gastric cancer in multivariate analyses. Vitamin D intake significantly correlated with the circulating 25-hydroxyvitamin D levels, but not with the active form of the vitamin, 1,25-dihydroxyvitamin D. There were no statistically significant interactions between vitamin D intake, and VDR or TXNIP polymorphisms. This study suggests that dietary vitamin D intake is not associated with gastric cancer risk, and the genetic polymorphisms of vitamin D-related genes do not modulate the effect of vitamin D with respect to gastric carcinogenesis.
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