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Zhenghui Gordon Jiang,Simon C. Robson,Zemin Yao.Journal of Biomedical Research,2013,27(1):1-13
Lipoprotein metabolism in nonalcoholic fatty liver disease
Received:July 10, 2012  
Keywords£ºnonalcoholic fatty liver disease (NAFLD), hepatic steatosis, nonalcoholic steatohepatitis, apolipo-protein, lipoprotein metabolism, very low density lipoprotein
Grant Program£º
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Zhenghui Gordon Jiang Department of Medicine, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA
Simon C. Robson Division of Gastroenterology, CLS612, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA
Zemin Yao Department of Biochemistry, Microbiology and Immunology, Ottawa Institute of Systems Biology, University of Ottawa, Ottawa,Ontario KIH 8M5, Canada
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Abstract £º
      Nonalcoholic fatty liver disease (NAFLD), an escalating health problem worldwide, covers a spectrum of pathologies characterized by fatty accumulation in hepatocytes in early stages, with potential progression to liver inflammation, fibrosis, and failure. A close, yet poorly understood link exists between NAFLD and dyslipidemia, a constellation of abnormalities in plasma lipoproteins including triglyceride-rich very low density lipoproteins. Apolipoproteins are a group of primarily liver-derived proteins found in serum lipoproteins; they not only play an extracellular role in lipid transport between vital organs through circulation, but also play an important intracellu-lar role in hepatic lipoprotein assembly and secretion. The liver functions as the central hub for lipoprotein metab-olism, as it dictates lipoprotein production and to a significant extent modulates lipoprotein clearance. Lipoprotein metabolism is an integral component of hepatocellular lipid homeostasis and is implicated in the pathogenesis, potential diagnosis, and treatment of NAFLD.