3.5

CiteScore

2.3

Impact Factor
  • ISSN 1674-8301
  • CN 32-1810/R
Hong Xie, Chen Wang, Xuemei Wu, Xia Liu, Shigang Qiao, Chunfeng Liu, Hong Liu. Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium[J]. The Journal of Biomedical Research, 2012, 26(1): 37-43. DOI: 10.1016/S1674-8301(12)60005-0
Citation: Hong Xie, Chen Wang, Xuemei Wu, Xia Liu, Shigang Qiao, Chunfeng Liu, Hong Liu. Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium[J]. The Journal of Biomedical Research, 2012, 26(1): 37-43. DOI: 10.1016/S1674-8301(12)60005-0

Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium

  • Parthenolide (PTN), a selective nuclear factor kappa B (NF-κB) inhibitor, has been used extensively to inhibit NF-κB activation. The duration of the inhibitory effect of PTN on NF-κB in vivo remains unclear. This study was to determine whether a lipopolysaccharide (LPS) challenge 6, 12 and 24 h after the administration of PTN could activate NF-κB. Rats were devided into five groups. The rats in the PTN, PTN+LPS and DMSO groups were in-jected intraperitoneally with PTN or DMSO. After 6, 12 or 24 h, LPS was administered in LPS and PTN+LPS groups. The expressions of NF-κB p50, IκBα and p-IκBα were inhibited in both PTN and PTN+LPS group at end of 6 and 12 h and no effects at 24 h. In summary, myocardial NF-κB expression occurs 1 h after the administration of LPS. PTN blocks this effect given at 6 h and no inhibitory effect 24 h after administration in vivo.
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