• Journal of Biomedical Research is a peer reviewed open access journal dedicated to publishing high-quality research in all areas of the biological and medical sciences.
Current Issue             Journal of Biomedical Research--2018, 32(4)
Luminal/extracellular domains of chimeric CI-M6PR-C proteins interfere with their retrograde endosome-to-TGN trafficking in the transient expression system
Fei Chang,Na Li,Kang Yan,Yumin Huang,Hongfei Xu,Yongjian Liu
The membrane trafficking of cation-independent mannose 6-phosphate receptor (CI-M6PR) between the transGolgi network (TGN) and endosomal compartments is not only critical for maintaining lysosomal function but also a well-known event for understanding molecular and cellular mechanisms in retrograde ...more>>
J Biomed Res 2018;32(4):245-256.   doi:10.7555/JBR.32.20180044
Dietary vitamin D intake and vitamin D related genetic polymorphisms are not associated with gastric cancer in a hospital-based case-control study in Korea
Sang-Yong Eom,Dong-Hyuk Yim,Dae-Hoon Kim,Hyo-Yung Yun,Young-Jin Song,SeiJin Youn,Taisun Hyun,Joo-Seung Park,Byung Sik Kim,Yong-Dae Kim,Heon Kim
There have been few studies on the association between vitamin D levels and gastric cancer in Asian populations, but no studies have been performed on the interactions between vitamin D intake and polymorphisms in the vitamin D pathway. The effects of vitamin D intake, vitamin D related genetic poly...more>>
J Biomed Res 2018;32(4):257-263.   doi:10.7555/JBR.32.20170089
Clinical features of multiple myeloma patients with isolated extramedullary relapse
Xiaoyan Qu,Lijuan Chen,Tian Tian,Limin Duan,Ruinan Lu,Hua Lu,Hanxin Wu,Jianyong Li
This study sought to analyze the clinical features and prognosis of multiple myeloma with isolated extramedullary relapse and with the absence of systemic progression. The clinical features and outcome were retrospectively analyzed in six multiple myeloma patients. These patients had secretory multi...more>>
J Biomed Res 2018;32(4):264-269.   doi:10.7555/JBR.31.20140090
2-Methyl-5H-benzo[d]pyrazolo[5,1-b][1,3]oxazin-5-imine, an edaravone analog, exerts neuroprotective effects against acute ischemic injury via inhibiting oxidative stress
Huanyu Ni,Yixuan Song,Haiyin Wu,Lei Chang,Chunxia Luo,Dongya Zhu
Oxidative stress plays an indispensable role in the pathogenesis of cerebral ischemia. Inhibiting oxidative stress has been considered as an effective approach for stroke treatment. Edaravone, a free radical scavenger, has been shown to prevent cerebral ischemic injury. However, the clinical efficac...more>>
J Biomed Res 2018;32(4):270-280.   doi:10.7555/JBR.32.20180014
Pitavastatin attenuates AGEs-induced mitophagy via inhibition of ROS generation in the mitochondria of cardiomyocytes
Zhimin Zha,Junhong Wang,Shiling Li,Yan Guo
This study aimed to investigate whether pitavastatin protected against injury induced by advanced glycation end products products (AGEs) in neonatal rat cardiomyocytes, and to examine the underlying mechanisms. Cardiomyocytes of neonatal rats were incubated for 48 hours with AGEs (100 mg/mL), recept...more>>
J Biomed Res 2018;32(4):281-287.   doi:10.7555/JBR.31.20160116
Pravastatin alleviates lipopolysaccharide-induced placental TLR4 over-activation and promotes uterine arteriole remodeling without impairing rat fetal development
Muyi Yang,Zhenyu Diao,Zhiyin Wang,Guijun Yan,Guangfeng Zhao,Mingming Zheng,Anyi Dai,Yimin Dai,Yali Hu
Preeclampsia is associated with over-activation of the innate immune system in the placenta, in which toll-like receptor 4 (TLR4) plays an essential part. With their potent anti-inflammatory effects, statins have been suggested as potential prevention or treatment of preeclampsia, although evidence ...more>>
J Biomed Res 2018;32(4):288-297.   doi:10.7555/JBR.32.20180039
A novel extradural nerve transfer technique by coaptation of C4 to C5 and C7 to C6 for treating isolated upper trunk avulsion of the brachial plexus
Kaixiang Yang,Shaohua Zhang,Dawei Ge,Tao Sui,Hongtao Chen,Xiaojian Cao
The study aimed to demonstrate the feasibility of an extradural nerve anastomosis technique for the restoration of a C5 and C6 avulsion of the brachial plexus. Nine fresh frozen human cadavers were used. The diameters, sizes, and locations of the extradural spinal nerve roots were observed. The leng...more>>
J Biomed Res 2018;32(4):298-304.   doi:10.7555/JBR.32.20180012
Serial lumbar puncture reduces cerebrospinal fluid (CSF) infection during removal of hemorrhagic CSF in aneurysmal subarachnoid hemorrhage after endovascular coiling
Chen Liang,Ling Yang,Shiwen Guo
The present study aimed to compare the complications and clinical outcomes of serial lumbar puncture (LP) and lumbar cerebrospinal fluid (CSF) drainage (LD) of patients with aneurysmal subarachnoid hemorrhage and provide more evidence to guide clinical management. In this retrospective study, 41 and...more>>
J Biomed Res 2018;32(4):305-310.   doi:10.7555/JBR.32.20170028
Psychotic due to bath salts and methamphetamines: emergency cesarean section under general anesthesia
Nina Schloemerkemper
The use of “bath salts” or other new psychoactive substances, otherwise known as “legal highs”, is increasing. Illicit drug use during pregnancy is not uncommon. Nevertheless, literature reporting bath salts and their effect on pregnancy is scant. Besides, there seems to be no literature about bath ...more>>
J Biomed Res 2018;32(4):311-313.   doi:10.7555/JBR.32.20180023
Identification of a LMNA (c.646C > T) variant by whole-exome sequencing in combination with a dilated cardiomyopathy (DCM) related gene filter in a family with familiar DCM
Liang Chen,Zhongyin Zhou,Huihe Lu,Ye Xie,Gang Li,Jianfei Huang,Dongsheng Zhao

J Biomed Res 2018;32(4):314-316.   doi:10.7555/JBR.32.20180003
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