• Journal of Biomedical Research is a peer reviewed open access journal dedicated to publishing high-quality research in all areas of the biological and medical sciences.
Current Issue             Journal of Biomedical Research--2018, 32(6)
Non-alcoholic fatty liver disease: a narrative review of genetics
Christopher J. Danford,Zemin Yao,Z. Gordon Jiang
Non-alcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver diseases worldwide. It encompasses a spectrum of disorders ranging from isolated hepatic steatosis to nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma. One of the key challen...more>>
J Biomed Res 2018;32(6):389-400.   doi:10.7555/JBR.32.20180045
Role of inflammasome regulation on immune modulators
Huijeong Ahn,Hyuk Moo Kwon,Eunsong Lee,Pyeung-Hyeun Kim,Eui-Bae Jeung,GeunShik Lee
Inflammatory responses are essential in eliminating harmful substrates from damaged tissue and inducing recovery. Several cytokines participate in and facilitate this response. Certain cytokines such as interleukin (IL)-1β and IL-18 are initially produced in precursor form in response to toll-like r...more>>
J Biomed Res 2018;32(6):401-410.   doi:10.7555/JBR.32.20170120
Preparation, optimization, and characterization of chitosancoated solid lipid nanoparticles for ocular drug delivery
Fengzhen Wang,Mingwan Zhang,Dongsheng Zhang,Yuan Huang,Li Chen,Sunmin Jiang,Kun Shi,Rui Li
The present study aimed to develop and optimize chitosan coated solid lipid nanoparticles (chitosan-SLNs) encapsulated with methazolamide. Chitosan-SLNs were successfully prepared by a modified oil-in-water emulsification-solvent evaporation method with glyceryl monostearate as the solid lipid and p...more>>
J Biomed Res 2018;32(6):411-423.   doi:10.7555/JBR.32.20160170
Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer
Huanqiang Wang,Congying Yang,Siyuan Wang,Tian Wang,Jingling Han,Kai Wei,Fucun Liu,Jida Xu,Xianzhen Peng,Jianming Wang
Identifying sensitive and specific biomarkers for early detection of cancer is immensely imperative for early diagnosis and treatment and better clinical outcome of cancer patients. This study aimed to construct a specific DNA methylation pattern of cancer suppressor genes and explore the feasibilit...more>>
J Biomed Res 2018;32(6):424-433.   doi:10.7555/JBR.32.20170065
Generation and functional characterization of a conditional Pumilio2 null allele
Kaibo Lin,Shikun Zhang,Jieli Chen,Ding Yang,Mengyi Zhu,Eugene Yujun Xu
The highly conserved RNA binding protein PUF (Pumilio/FBF) family is present throughout eukaryotes from yeast to mammals, with critical roles in development, fertility and the nervous system. However, the function of the mammalian PUF family members remains underexplored. Our previous study reported...more>>
J Biomed Res 2018;32(6):434-441.   doi:10.7555/JBR.32.20170117
Effects of chemotherapeutic agent bendamustine for nonhodgkin lymphoma on spermatogenesis in mice
Minbo Zang,Qiao Zhou,Yunfei Zhu,Mingxi Liu,Zuomin Zhou
Non-Hodgkin lymphoma (NHL) is one of the most common cancers affecting men of reproductive age. The high response rate of bendamustine as first-line reatment for NHL, coupled with young age of patients, makes elucidation of the impact of treatment on male reproduction important. Our aim was to dete...more>>
J Biomed Res 2018;32(6):442-453.   doi:10.7555/JBR.31.20170023
Biomechanical characterization of a novel ring connector for sutureless aortic anastomosis
Huan Liu,Shijiang Zhang,Yongfeng Shao,Xiaohu Lu,Weidong Gu,Buqing Ni,Qun Gu,Junjie Du
The surgical treatment for aortic diseases remains a challenge for any cardiac surgeon. The use of sutureless ring connector in aortic anastomosis can simplify the procedure and shorten anastomosis time. Therefore, we developed a novel device for sutureless aortic anastomosis. A series of experiment...more>>
J Biomed Res 2018;32(6):454-460.   doi:10.7555/JBR.31.20170011
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