• Journal of Biomedical Research is a peer reviewed open access journal dedicated to publishing high-quality research in all areas of the biological and medical sciences.
Current Issue             Journal of Biomedical Research--2018, 32(5)
REVIEW ARTICLES
Immune checkpoint inhibitors in cancer therapy
Eika S. Webb,Peng Liu,Renato Baleeiro,Nicholas R. Lemoine,Ming Yuan,Yaohe Wang
In recent years immune checkpoint inhibitors have garnered attention as being one of the most promising types of immunotherapy on the horizon. There has been particular focus on the immune checkpoint molecules, cytotoxic Tlymphocyte antigen-4 (CTLA-4) and programmed cell death protein 1 (PD-1) which...more>>
J Biomed Res 2018;32(5):317-326.   doi:10.7555/JBR.31.20160168
Non-alcoholic fatty liver disease–a chronic disease of the 21st century
Peter Metrakos,Tommy Nilsson
Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of metabolic states ranging from simple steatosis o inflammation with associated fibrosis to cirrhosis. Though accumulation of hepatic fat is not associated with a ignificant increase in mortality rates, hepatic inflammation is, as this ...more>>
J Biomed Res 2018;32(5):327-335.   doi:10.7555/JBR.31.20160153
ORIGINAL ARTICLES
Association of serum lipids and severity of epithelial ovarian cancer: an observational cohort study of 349 Chinese patients
Yi Zhang,Jing Wu,Junya Liang,Xing Huang,Lei Xia,Dawei Ma,Xinyu Xu,Pingping Wu
While obesity and fat intake have been associated with the risk and prognosis of epithelial ovarian cancer, the association between the lipid levels and epithelial ovarian cancer phenotype remains controversial. We conducted a retrospective study of 349 epithelial ovarian cancer patients who receive...more>>
J Biomed Res 2018;32(5):336-342.   doi:doi.org/10.7555/JBR.32.20170096
Prostate cancer tends to metastasize in the bone-mimicking microenvironment via activating NF-kB signaling
Haibo Tong,Chunlin Zou,Siyuan Qin,Jie Meng,Evan T. Keller,Jian Zhang,Yi Lu
Prostate cancer preferentially metastasizes to the bone. However, the underlying molecular mechanisms are still unclear. To explore the effects of a bone-mimicking microenvironment on PC3 prostate cancer cell growth and metastasis, we used osteoblast differentiation medium (ODM; minimal essential me...more>>
J Biomed Res 2018;32(5):343-353.   doi:10.7555/JBR.32.20180035
Pretreatment with simvastatin upregulates expression of BK-2R and CD11b in the ischemic penumbra of rats
Jianying Zhang,Qingke Bai,Yingdong Zhang
Inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductases, collectively known as statins, have been shown to minimize cerebral ischemic events in patients. We assessed the mechanisms of simvastatin pretreatment in preventing cerebral ischemia/reperfusion injury in rats using a model of middle c...more>>
J Biomed Res 2018;32(5):354-360.   doi:10.7555/JBR.32.20160152
Pathway-based analysis of genome-wide association study of circadian phenotypes
Didi Zhu,Jiamin Yuan,Rui Zhu,Yao Wang,Zhiyong Qian,Jiangang Zou
Sleepiness affects normal social life, which attracts more and more attention. Circadian phenotypes contribute to obvious individual differences in susceptibility to sleepiness. We aimed to identify candidate single nucleotide polymorphisms (SNPs) which may cause circadian phenotypes, elucidate the ...more>>
J Biomed Res 2018;32(5):361-370.   doi:10.7555/JBR.32.20170102
Hydroxytyrosol and olive leaf extract exert cardioprotective effects by inhibiting GRP78 and CHOP expression
Lixing Wu,Yuyu Xu,Zhijian Yang,Qing Feng
Myocardial infarction triggers massive biochemical changes, even cardiac cell death. Endoplasmic reticulum stress is involved in the pathology of myocardial infarction-mediated apoptosis. In the present study, myocardial cell line H9c2 cells were treated with cobalt chloride (CoCl2) to induce hypoxi...more>>
J Biomed Res 2018;32(5):371-379.   doi:10.7555/JBR.32.20170111
Antifungal effects of BiOBr nanosheets carrying surfactant cetyltrimethylammonium bromide
Meiqing Sun,Zhanlin Ding,Hong Wang,Guangping Yu,Bingzhi Li,Mingchun Li,Mengmeng Zhen
BiOBr nanosheets are important photocatalytic nanomaterials. However, their biological effects remain to be explored. In this study, we investigated the antifungal effect of BiOBr nanosheets on Candida albicans. Strikingly, the nanosheets strongly inhibited the growth of C. albicans [IC50=(964.7) m...more>>
J Biomed Res 2018;32(5):380-388.   doi:10.7555/JBR.32.20180043
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Top Journal Content
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